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15mg/vial *10 vials

Retatrutide (LY-3437943) is a triple hormone receptor agonist of GLP-1, GIP, and GCGR receptors. Research has shown it to achieve a more than 24% mean weight reduction in non-diabetic obese or overweight adults during a phase 2 trial.

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Description

Buy Retatrutide 15mg – Balanced Appetite Control & Metabolic Support

Stay in control of your transformation with Retatrutide 15mg, a next-generation peptide designed to support appetite regulation, fat loss, and metabolic efficiency.

With its advanced multi-pathway action, Retatrutide helps manage hunger signals, improve energy balance, and support a steady, sustainable approach to achieving a leaner physique.


Key Benefits

  • 🔹 Helps control hunger and cravings
  • 🔹 Promotes steady, sustainable weight loss
  • 🔹 Supports metabolic performance
  • 🔹 Aids in energy balance and efficiency
  • 🔹 Encourages a leaner, more defined body composition

Why Choose 15mg?

The 15mg option is ideal for those looking for a moderate, controlled approach, offering effective support while maintaining flexibility in use.

Perfect for progression phases, structured plans, or maintaining results.


Product Highlights

  • ✔ 15mg peptide concentration
  • ✔ Multi-pathway (triple-action) peptide
  • ✔ High-quality, consistent formulation
  • ✔ Suitable for structured weight management

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About Retatrutide (LY3437943)

Retatrutide (research code LY3437943) is a cutting-edge research peptide and a novel next-generation triple agonist. It is the first molecule of its class to highly selectively and simultaneously bind to three crucial metabolic receptors: the GIP receptor (glucose-dependent insulinotropic polypeptide), the GLP-1 receptor (glucagon-like peptide-1), and the Glucagon receptor (GCG-R).

This unique triple mechanism of action sets Retatrutide fundamentally apart from previous dual agonists like Tirzepatide or mono-agonists like Semaglutide. While GIP and GLP-1 primarily modulate insulin secretion and control satiety via the central nervous system, the additional activation of the glucagon receptor opens up an entirely new metabolic pathway. This pathway directly targets the increase of basal energy expenditure and promotes hepatic lipid oxidation (fat burning in the liver). This synergistic effect makes Retatrutide one of the most promising and intensely studied peptides in global metabolic research.

Groundbreaking Study Results: The Scientific Foundation

The scientific and clinical relevance of Retatrutide is supported, among other data, by the highly acclaimed Phase 2 study by Jastreboff et al., published in 2023 in the prestigious New England Journal of Medicine (NEJM) (PubMed ID: 37385275). In this randomized, double-blind, and placebo-controlled trial, the peptide demonstrated unprecedented results over a 48-week period:

  • Significant Weight Reduction: In the highest dosage group evaluated, a dose-dependent reduction in body weight of up to 24.2% was achieved—a figure that significantly surpasses previously published results for comparable substances in obesity and metabolic research.
  • Improvement of Cardiometabolic Parameters: Alongside massive weight loss, significant improvements were observed in essential biomarkers, including optimized HbA1c levels, lowered fasting glucose, and a marked enhancement of the lipid profile.
  • Liver Health: Particularly noteworthy were the positive effects on the reduction of liver fat, making Retatrutide a highly interesting candidate for research models focusing on NAFLD (non-alcoholic fatty liver disease) and NASH.

Biochemical Properties and Stability

At Bergdorf Bioscience, Retatrutide is supplied as a high-purity, lyophilized (freeze-dried) powder. This complex manufacturing process extracts moisture from the peptide, ensuring maximum chemical stability and an exceptionally long shelf life, even at room temperature.

  • Amino Acid Sequence: His-Geranylgeranyl-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Glu-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
  • Biological Half-Life: The half-life of Retatrutide is approximately six days. For researchers working with in vivo models, this allows for extended administration intervals and more stable plasma levels.

Buy Retatrutide at Bergdorf Bioscience: Quality for the Highest Demands

When you buy Retatrutide for your laboratory, you need absolute reliability. To guarantee maximum flexibility for a wide variety of research protocols and dose-finding studies, Retatrutide is available at Bergdorf Bioscience in five precisely graduated dosages:

  • 10 mg
  • 15 mg
  • 20 mg
  • 30 mg
  • 50 mg

Each vial is filled under the strictest laboratory conditions and individually sealed. All batches are analyzed using High-Performance Liquid Chromatography (HPLC) and feature a guaranteed purity of at least 99%. Our uncompromising quality assurance also includes detailed mass spectrometry to confirm the exact molecular weight, as well as rigorous endotoxin testing.

Worldwide Shipping – Safe and Hassle-Free

We offer reliable worldwide shipping for all our research peptides. Thanks to professional lyophilization, the Retatrutide powder is highly temperature-stable in its unmixed state. The molecular integrity and high biological activity of the peptide are fully preserved at normal ambient temperatures throughout the global transit. However, after reconstitution (mixing with bacteriostatic water), we highly recommend proper storage in a refrigerator.

Mechanism of action

Simultaneous GLP-1R, GIPR, and GCGR agonism: GLP-1R enhances insulin secretion and reduces appetite; GIPR potentiates insulin and attenuates nausea; GCGR stimulates hepatic lipolysis, thermogenesis, and energy expenditure

Typical research dosage

Beginner protocol

0.5 mg / Woche

Advanced protocol

2–12 mg/Woche (Forschungskontext)

Note: The dosages listed correspond to typical ranges from published research literature. They do not replace advice from a qualified researcher or physician.

Quality, purity & batch documentation

Every batch is analyzed by an independent laboratory via HPLC before shipment. We document purity (avg. 99.43% in 2026), mass spectrometry identity, and sterility. Production follows GMP standards in ISO-certified laboratories.

Frequently asked questions

Can I buy retatrutide?

When will retatrutide come to market?

Eli Lilly is running the Phase-3 studies (TRIUMPH program) through 2026. EU marketing authorisation as a medicinal product is expected no earlier than 2027. As a research reference substance, retatrutide is already available today.

How much does retatrutide cost?

Is retatrutide prescription-only?

What is the difference between retatrutide and tirzepatide?

How long is the half-life of retatrutide?

Who manufactures retatrutide?

For research purposes only (RUO). Not for human consumption.

Research details

Specifications

CAS no.2381089-83-2
FormulaC₂₂₁H₃₄₂N₄₆O₆₈
Molar mass4 731 g/mol
SynonymsLY3437943, LY-3437943
Purity (HPLC)≥ 99%
Half-life~6 days
FormLyophilized powder
Storage2–8 °C, protected from light
Stability24 months lyophilized
After reconstitution28 days @ 2–8 °C

Reconstitution calculator

10mg vial + 2 ml BAC water → concentration:

Per unit (10 IU)

0.50 mg

Open full calculator

Half-life profile

Wk 1Wk 2Wk 3Wk 4Steady state

Steady-state plasma level after ~ 4 weeks with weekly administration.

Scientific references

  • Jastreboff et al. · NEJM, 2023

    Triple-Hormone-Receptor Agonist Retatrutide for Obesity

  • Coskun et al. · Cell Metab, 2022

    LY3437943 Triple GIP/GLP-1/Glucagon Receptor Agonist Discovery

  • Rosenstock et al. · Lancet, 2023

    Retatrutide Phase 2 Trial in Type 2 Diabetes

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  • Dosage
  • Quality
  • FAQ

Customer Reviews


Important Note

For best results, combine with a balanced diet and active lifestyle. Responsible use and professional guidance are recommended.

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